Potential Population-level Health Impact and Cost-effectiveness of an Adult TB Vaccine in South Africa

Project pitch

• Get a hand experience on implementing a simple TB model, with vaccine efficacy and coverage. Learn extraction.
• Overall aim to estimate the population-level health impact and cost effectiveness of an adult TB vaccine in South Africa.
• Modify model structure SEIR, the E state to incorporate vaccine and coverage. R code will be provided.
• Simple calibration approach to SA TB mortality data from Statistics South Africa.
  • Will provide 1997-2020 extract and show how it was cleaned, adjusted for completeness.
• Estimate impact of vaccine.
• If there is time: Estimate costs and cost-effectiveness

Research area(s)

• Infectious disease dynamics
• Cost-effectiveness analyses
• Epidemiological
• Public health impact
• TB

Data

Type of data

Publicly available recorded deaths from the vital register.

Source

Statistics South Africa

Description and status of data

• Will provide the adjusted and cleaned extraction 1997-2020.
• Description of the process will be provided.
• Literature based input costs:
  • vaccine
  • testing
  • treatment

Software

Will use R.

Potential research question(s)

• What is the impact of an TB vaccine on TB incidence and mortality 2030-2040?

Resources

• TB natural history model (link to follow)
• Illustration of cleaning TB mortality data (link to follow)
• STATSA